Pandemic infection forecasting through compartmental model and learning-based approaches (preprint)

The emergence and spread of deadly pandemics has repeatedly occurred throughout history, causing widespread infections and loss of life. The rapid spread of pandemics have made governments across the world adopt a range of actions, including non-pharmaceutical measures to contain its impact. However, the dynamic nature of pandemics makes selecting intervention strategies challenging. Hence, the development of suitable monitoring and forecasting tools for tracking infected cases is crucial for designing and implementing effective measures. Motivated by this, we present a hybrid pandemic infection forecasting methodology that integrates compartmental model and learning-based approaches. In particular, we develop a compartmental model that includes time-varying infection rates, which are the key parameters that determine the pandemic's evolution. To identify the time-dependent infection rates, we establish a hybrid methodology that combines the developed compartmental model and tools from optimization and neural networks. Specifically, the proposed methodology estimates the infection rates by fitting the model to available data, regarding the COVID-19 pandemic in Cyprus, and then predicting their future values through either a) extrapolation, or b) feeding them to neural networks. The developed approach exhibits strong accuracy in predicting infections seven days in advance, achieving low average percentage errors both using the extrapolation (9.90%) and neural network (5.04%) approaches.

A Study of Data-driven Methods for Adaptive Forecasting of COVID-19 Cases (preprint)

Severe acute respiratory disease SARS-CoV-2 has had a found impact on public health systems and healthcare emergency response especially with respect to making decisions on the most effective measures to be taken at any given time. As demonstrated throughout the last three years with COVID-19, the prediction of the number of positive cases can be an effective way to facilitate decision-making. However, the limited availability of data and the highly dynamic and uncertain nature of the virus transmissibility makes this task very challenging. Aiming at investigating these challenges and in order to address this problem, this work studies data-driven (learning, statistical) methods for incrementally training models to adapt to these nonstationary conditions. An extensive empirical study is conducted to examine various characteristics, such as, performance analysis on a per virus wave basis, feature extraction, "lookback" window size, memory size, all for next-, 7-, and 14-day forecasting tasks. We demonstrate that the incremental learning framework can successfully address the aforementioned challenges and perform well during outbreaks, providing accurate predictions.